The park enjoys a prolific population of birds with over 600 species living or migrating through the region including the threatened corncrake and near threatened Basra Reed Warbler as well as the white-headed buffalo weaver recognized by its bright-red rump. The chain of lakes fed by Mzima Springs swarm with fish, large crocodiles, and some big pods of hippos. The rhino sanctuary is working hard to bring back the black rhino population after some devastating poaching in the 1960s and on.

The local safari lodges and camps offer daily game drives through the park in comfortable 4×4 vehicles conducted by expert guides and trackers. This is the best way to spot wildlife. A guided nature walk or bird-watching walk takes a closer look at the area’s flora and fauna as well as observing smaller animals often missed from the vehicles. The rocky cliffs of Tsavo West are a favorite spot for rock-climbing with the most impressive piece of rock being the 984-foot high east face of Kichwa Tembo. The Ivory Tower on Elephant Rocks is a newer climbing spot that ranks with the best and hardest bush climb in Kenya. There also many caves to explore in the area. At Mzima Springs, there is a unique underwater hippo-viewing chamber.